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E5 is located in the membrane of infected cells, where it binds to the epidermal growth factor receptor (EGFR), promoting its dimerization and activation, resulting in mitogenic signals to the nucleus, and thus stimulating cell proliferation [31]

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Ginseng is mainly found in North America and in the Northern Hemisphere of eastern Asia in areas such as Korea, Bhutan and eastern Siberia

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Its typically caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke

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